Links to Published Research
The Nrf2 Cell Defense Pathway*
Role of Nrf2 in combatting oxidative damage and toxicity:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680839/
Nrf2 protects against oxidative stress by maintaining reduced glutathione:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634824/
The dangers of reactive oxygen species and free radicals:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2769059/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909187/
Rising levels of atmospheric oxygen and the evolution of Nrf2:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906274/
Nrf2, Keap1, and the sensor of chemical threats:
https://pdfs.semanticscholar.org/8e8e/b404d667ad5f59ecd5b56248a9407aabb8d4.pdf
http://europepmc.org/articles/pmc4726722
Large number of protective genes regulated by Nrf2:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943601/
Nrf2 also protects against toxic environmental pollutants:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2585047/
Alkyl catechols are vital natural Nrf2 activators, and Nrf2 activation by oxidative stress is poor in the absence of Nrf2 co-factors
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0148042
A key chemical feature of effective Nrf2 activators is "oxidation-reduction lability" that facilitates electron exchange
